Modified release of drug delivery systems: Hydrophilic polymers [Formas farmacêuticas de liberação modificada: Polímeros hidrifílicos]

• Tipo: Outra Publicação em Revista Científica Internacional
• Data: 2005

Autores

lopes, cm (Autor) Outra; lobo, jms (Autor) Outra; costa, p (Autor) FFUP

Revista

Título: Revista Brasileira de Ciencias Farmaceuticas/Brazilian Journal of Pharmaceutical Sciences

Vol. 41

Páginas: 143-154

ISSN: 1516-9332

Editora: Universidade de São Paulo

Indexação

ISI Web of Knowledge

Scopus - 91 Citações

Outras Informações

ID Authenticus: P-007-E5Z

Abstract (EN): Drug delivery systems (DDS) became an integral part of pharmaceutical research. The majority of oral DDS are matrix-based systems. Hydrophilic matrices for the past two decades have been popular in the formulation of controlled release solid dosage forms. Swellable matrices are monolithic systems prepared by compression of a powdered mixture of a hydrophilic polymer and a drug. They represent a delivery system in which various mechanisms can be adapted to the delivery program. Their success is linked to the established tabletting technology of manufacture. The choice of the hydrophilic polymer in the matrix formulation can provide an appropriate combination of swelling, dissolution or erosion mechanisms to evaluate in vitro release kinetics.

Idioma: Português

Tipo (Avaliação Docente): Científica

Nº de páginas: 12