Enhancing proteasome-inhibitor effect by functionalized gold nanoparticles

• Tipo: Artigo em Revista Científica Internacional
• Data: 2014

Autores

Silvia Castro Coelho (Autor) FEUP; Sandra Rocha (Autor) FEUP; Maria do Carmo Pereira (Autor) FEUP; Petras Juzenas (Autor) Outra; Manuel A. N. Coelho (Autor) FEUP

Revista

Título: Journal of Biomedical Nanotechnology

Vol. 10 Nº 5

Páginas: 717-723

ISSN: 1550-7033

Editora: American Scientific Publishers

Indexação

ISI Web of Knowledge - 13 Citações

Scopus - 14 Citações

Projetos Associados

BIONANO - Distibuição de biomoleculas através de nanopartículas inorganica/organicas

Outras Informações

ID Authenticus: P-009-CQY

DOI: 10.1166/jbn.2014.1743

Abstract (EN): Colloidal gold nanoparticles intensify the anticancer response of the drug bortezomib, a proteasome inhibitor. Polyethylene glycol-coated gold nanoparticles and the drug show a synergistic effect in reducing the cell viability of prostate cancer cell line Du145. It was observed a significant cell viability reduction with bortezomib concentrations as low as 4 nM. The proteasome inhibitor alone had to be present at concentrations in the ranger of 120 nM to induce identical cytotoxicity response. These findings demonstrate that gold nanoparticles enhancing the permeation and retention (EPR) effect in Du145 cells and open the possibility to decrease multi-drug resistance (MDR). The in vitro results of functionalized gold nanoparticles, internalized by cancer cells, pave the way for a more efficient proteasome inhibitor delivery and release in adenocarcinoma cells. Copyright

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 7