Is BRAF mutation screening useful for preoperative risk stratification in papillary thyroid cancer?

• Tipo: Artigo em Revista Científica Internacional
• Data: 2009

Autores

Paula Soares (Autor) FMUP; Manuel Sobrinho Simoes (Autor) FMUP

Revista

Título: Future Oncology

Vol. 5

Páginas: 1225-1229

ISSN: 1479-6694

Editora: Future Medicine Ltd.

Indexação

ISI Web of Knowledge - 2 Citações

Scopus - 4 Citações

Classificação Científica

FOS: Ciências médicas e da saúde > Medicina clínica

Outras Informações

ID Authenticus: P-003-FB7

DOI: 10.2217/fon.09.81

Abstract (EN): Evaluation of: Xing M, Clark D, Guan H et al.: BRAF mutation testing of thyroid fine-needle aspiration biopsy specimens for preoperative risk stratification in papillary thyroid cancer. J. Clin. Oncol. 27(18), 2977-2982 (2009). Although the majority of patients with papillary thyroid cancer are effectively treated with thyroidectomy and selective use of postoperative (131)I therapy, disease persistence/recurrence can afflict a proportion of patients after the initial treatments, BRAF mutations, present in a large proportion of papillary thyroid cancers, illustrate one of the most impressive examples of phenotype-genotype correlation in human pathology. In this study, the authors propose that preoperative BRAF mutation testing of fine-needle aspiration biopsy specimens provides a novel tool for a preoperative risk stratification strategy for predicting the extent of initial disease and subsequent clinical outcomes.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 5