In Vivo Biocompatibility and Biodegradability of Dextrin-based Hydrogels

• Tipo: Artigo em Revista Científica Internacional
• Data: 2010

Autores

Susana Moreira (Autor) Outra; Gil da Costa, R. M. (Autor) FEUP; Luisa Guardao (Autor) Outra; Fatima Gaertner (Autor) Outra; Manuel Vilanova (Autor) ICBAS; Miguel Gama (Autor) Outra

Revista

Título: Journal of Bioactive and Compatible Polymers

Vol. 25 Nº 2

Páginas: 141-153

ISSN: 0883-9115

Editora: SAGE

Indexação

ISI Web of Knowledge - 18 Citações

Scopus - 17 Citações

Classificação Científica

FOS: Ciências da engenharia e tecnologias > Engenharia dos materiais

Outras Informações

ID Authenticus: P-003-8QM

DOI: 10.1177/0883911509357865

Abstract (EN): The in vivo biocompatibility of dextrin hydrogels obtained by polymerization of dextrin-hydroxyethylmethacrylate (dextrin-HEMA) and dextrin-vinyl acrylate (dextrin-VA) are reported in this work. The histological analysis of subcutaneous implants of these hydrogels, featuring inflammatory and reabsorption events, were carried out over a 16-week period in mice. The dextrin-HEMA hydrogel was quickly and completely degraded and reabsorbed, whereas the dextrin-VA degradation occurred slowly and a thin fibrous capsule surrounded the nondegradable hydrogel. The dextrin-HEMA was degraded after 16 weeks with only mild inflammation and a few detectable foamy macrophages around the implant. These events were followed by complete resorption and no sign of capsule formation or fibrosis associated to the implants. The results indicate that the dextrin hydrogels are biocompatible because no toxicity on the tissues surrounding the implants was found. It may be speculated that a controlled degradation rate of the hydrogels may be obtained by grafting dextrin to HEMA and VA in different proportions.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 13