FIA TITRATIONS OF EPHEDRINE IN PHARMACEUTICAL FORMULATIONS WITH A PVC TETRAPHENYLBORATE TUBULAR ELECTRODE

• Tipo: Artigo em Revista Científica Internacional
• Data: 1995

Autores

ALCADA, MNMP (Autor) FMUP; LIMA, JLFC (Autor) FFUP; MONTENEGRO, MCBSM (Autor) FFUP

Revista

Título: Journal of Pharmaceutical and Biomedical Analysis

Vol. 13

Páginas: 459-464

ISSN: 0731-7085

Editora: Elsevier

Indexação

ISI Web of Knowledge - 12 Citações

Scopus - 10 Citações

Classificação Científica

FOS: Ciências exactas e naturais > Química

Outras Informações

ID Authenticus: P-001-H4A

DOI: 10.1016/0731-7085(95)01323-d

Abstract (EN): A flow injection system for the titration of ephedrine in pharmaceutical products with potentiometric detection was developed. For this purpose a tetraphenylborate tubular electrode was constructed. The electrode was prepared without inner reference solution and with a PVC membrane based on tetrapentylammonium tetraphenylborate as ion exchanger and 2-nitrophenylphenyl ether as mediator solvent. Its operational characteristics were evaluated in a low dispersion manifold and compared with more conventionally shaped electrodes using the same sensor. In the pH range 2.5-11.5, the electrodes showed linear response between 3.8 x 10(-6) and 0.1 M with a slope of -56.4 mV/log[BPh4]. Ephedrine determinations in pharmaceutical products were carried out in a single channel manifold with a mixing chamber incorporated and using the tubular electrode as detector. Recovery rates of 98.6 +/- 2.5% were obtained in the analysis of tables, nasal drops and syrups with a sampling rate of about 60 h(-1).

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 6