Effect of Human Serum Proteins on Pure Hydroxyapatite and Silicon Substituted Hydroxyapatatite: AFM and SEM Studies

• Tipo: Artigo em Revista Científica Internacional
• Data: 2004

Autores

Cláudia M. Botelho (Autor) Outra; Maria Ascensão Lopes (Autor) FEUP; D. J. Stokes (Autor) Outra; R. A. Brooks (Autor) Outra; S. Best (Autor) Outra; José Domingos Santos (Autor) FEUP; N. Rushton (Autor) Outra; W. Bonfield (Autor) Outra

Revista

Título: Materials Science Forum

Vol. 455-456

Páginas: 378-382

ISSN: 0255-5476

Editora: Trans Tech Publications Ltd

Indexação

ISI Web of Science

Classificação Científica

FOS: Ciências da engenharia e tecnologias > Engenharia médica

CORDIS: Ciências Tecnológicas > Engenharia > Engenharia de materiais

Outras Informações

ID Authenticus: P-00T-AT5

DOI: 10.4028/www.scientific.net/msf.455-456.378

Abstract (EN): Human serum proteins adhere to calcium phosphate within seconds after implantation. This layer influences the biological behaviour of the biomaterials. Hydroxyapatite (HA) and 0.8 wt% of silicon substituted hydroxyapatite (Si-HA) were incubated in three different solutions; simulated body fluid, simulated body fluid with 0.1 % and 10 % in volume of human serum. The surface of Si-HA underwent significant surface changes more rapidly than the HA surface. After a period of 7 days incubation in SBF an apatite layer was observed by ESEM and AFM on the Si-HA surface, but not on the HA surface. At the HA surface calcium phosphate deposits were only observed after 28 days of incubation. The formation of an apatite layer on the surface of both materials seems to have been delayed with the addition of human serum proteins.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 5