Development and characterization of novel alginate-based hydrogels as vehicles for bone substitutes

• Tipo: Artigo em Revista Científica Internacional
• Data: 2013

Autores

Morais, DS (Autor) Outra; Rodrigues, MA (Autor) Outra; Silva, TI (Autor) Outra; Lopes, MA (Autor) FEUP; Santos, M (Autor) Outra; Santos, JD (Autor) FEUP; Botelho, CM (Autor) Outra

Revista

Título: Carbohydrate Polymers

Vol. 95

Páginas: 134-142

ISSN: 0144-8617

Editora: Elsevier

Indexação

ISI Web of Knowledge - 29 Citações

ISI Web of Science

Scopus - 39 Citações

Classificação Científica

FOS: Ciências exactas e naturais > Química

CORDIS: Ciências Tecnológicas > Engenharia > Engenharia de biomateriais

Outras Informações

ID Authenticus: P-005-0T4

DOI: 10.1016/j.carbpol.2013.02.067

Abstract (EN): In this work three different hydrogels were developed to associate, as vehicles, with the synthetic bone substitute GR-HAP. One based on an alginate matrix (Alg); a second on a mixture of alginate and chitosan (Alg/Ch); and a third on alginate and hyaluronate (Alg/HA), using Ca2+ ions as cross-linking agents. The hydrogels, as well as the respective injectable bone substitutes (IBSs), were fully characterized from the physical-chemical point of view. Weight change studies proved that all hydrogels were able to swell and degrade within 72 h at pH 7.4 and 4.0, being Alg/HA the hydrogel with the highest degradation rate (80%). Rheology studies demonstrated that all hydrogels are non-Newtonian viscoelastic fluids, and injectability tests showed that IBSs presented low maximum extrusion forces, as well as quite stable average forces. In conclusion, the studied hydrogels present the necessary features to be successfully used as vehicles of GR-HAP, particularly the hydrogel Alg/HA.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 9