Electrochemical Study of the Anticancer Drug Daunorubicin at a Water/Oil Interface: Drug Lipophilicity and Quantification

• Tipo: Artigo em Revista Científica Internacional
• Data: 2013

Autores

Jose A Ribeiro (Autor) Outra; Silva, F (Autor) FCUP; Carlos M Pereira (Autor) FCUP

Revista

Título: Analytical Chemistry

Vol. 85

Páginas: 1582-1590

ISSN: 0003-2700

Editora: American Chemical Society

Indexação

ISI Web of Knowledge - 58 Citações

Scopus - 60 Citações

Classificação Científica

FOS: Ciências exactas e naturais > Química

Outras Informações

ID Authenticus: P-002-0JG

DOI: 10.1021/ac3028245

Abstract (EN): In this work, the ion transfer mechanism of the anticancer drug daunorubicin (DNR) at a liquid/liquid interface has been studied for the first time. This study was carried out using electrochemical techniques, namely cyclic voltammetry (CV) and differential pulse voltammetry (DPV). The lipophilicity of DNR was investigated at the water/1,6-dichlorohexane (DCH) interface, and the results obtained were presented in the form of an ionic partition diagram. The partition coefficients of both neutral and ionic forms of the drug were determined. The analytical parameter for the detection of DNR was also investigated in this work. An electrochemical DNR sensor is proposed by means of simple ion transfer at the water/DCH interface, using DPV as the quantification technique. Experimental conditions for the analytical determination of DNR were established, and a detection limit of 0.80 mu M was obtained.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 9