Anticomplementary activity of dolabranes from Endospermum diadenum

• Tipo: Artigo em Revista Científica Internacional
• Data: 1998

Autores

Nascimento, MSJ (Autor) FFUP; Pinto, MMM (Autor) FFUP; Vieira, LM (Autor) ICBAS; Kijjoa, A (Autor) ICBAS; Silva, AMS (Autor) Outra; Kroes, BH (Autor) Outra; Labadie, RP (Autor) Outra

Revista

Título: Pharmaceutical and Pharmacological Letters

Vol. 8

Páginas: 93-96

ISSN: 0939-9488

Editora: Stuttgart Medpharm Scientific Publishers

Indexação

ISI Web of Knowledge

Scopus - 4 Citações

Outras Informações

ID Authenticus: P-007-81A

Abstract (EN): Four dolabrane diterpenes and a norseco isolated from Endospermum diadenum, were tested for their influence on the classical and alternative pathways of the human complement systems. While the dolabranes showed a strong inhibition on the classical pathway in a dose dependent manner, the norseco analogue was found to be inactive. None of the compounds showed activity on the alternative pathway of complement. The findings of this study suggest that the anticomplementary activity of some dolabranes, in particular dolabrane 1e is probably brought about through interaction with one or more complement factors. Ca2+ chelation is not likely to be mainly involved in the anticomplementary activity found.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 4