Substituted Pyrazolo[3,4- d ]pyrimidines: Microwave-Assisted, Solvent-Free Synthesis and Biological Evaluation

• Tipo: Artigo em Revista Científica Internacional
• Data: 2008

Autores

oliveira-campos, amf (Autor) Outra; sivasubramanian, a (Autor) Outra; rodrigues, lm (Autor) Outra; seijas, ja (Autor) Outra; vazquez-tato, mp (Autor) Outra; peixoto, f (Autor) Outra; abreu, cg (Autor) Outra; cidade, h (Autor) FFUP; oliveira, ae (Autor) Outra; pinto, m (Autor) FFUP

Revista

Título: Helvetica Chimica Acta

Vol. 91 Nº 7

Páginas: 1336-1345

ISSN: 0018-019X

Editora: Wiley-Blackwell

Indexação

ISI Web of Knowledge - 13 Citações

Scopus - 16 Citações

Classificação Científica

FOS: Ciências exactas e naturais > Química

Outras Informações

ID Authenticus: P-00G-YK8

DOI: 10.1002/hlca.200890145

Abstract (EN): A simple and efficient method has been developed for the synthesis of various pyrazolo[3,4-d]pyrimidines by using microwave irradiation under solvent-free conditions. The advantages of applying microwave irradiation compared with the classical method were demonstrated. The structures of all the compounds were confirmed by the usual techniques and, in two cases, by X-ray analysis. The compounds did not display appreciable ability to inhibit xanthine oxidase activity. Screening for antifungal activity showed that some derivatives were active against four fungi, with more significant results for Botrytis.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 10