Resolution and determination of enantiomeric purity of new chiral derivatives of xanthones using polysaccharide-based stationary phases

• Tipo: Artigo em Revista Científica Internacional
• Data: 2012

Autores

Carla Fernandes (Autor) FFUP; Pedro Brandao (Autor) Outra; Alexandre Santos (Autor) Outra; M E Tiritan (Autor) FFUP; Carlos Afonso (Autor) FFUP; Quezia B Cass (Autor) Outra; Madalena M Pinto (Autor) FFUP

Revista

Título: Journal of Chromatography A

Vol. 1269

Páginas: 143-153

ISSN: 0021-9673

Editora: Elsevier

Indexação

ISI Web of Knowledge - 26 Citações

Scopus - 26 Citações

Classificação Científica

FOS: Ciências exactas e naturais > Química

Outras Informações

ID Authenticus: P-002-2AY

DOI: 10.1016/j.chroma.2012.07.058

Abstract (EN): The enantioresolution and determination of the enantiomeric purity of 24 new chiral derivatives of xanthones (CDXs) were investigated on polysaccharide-based chiral stationary phases (CSPs). The tris-3.5-dimethylphenylcarbamates of cellulose and amylose and tris-3,5-dimethoxyphenylcarbamate of amylose were selected as CSPs for this work. The separation of enantiomeric mixtures of CDXs was explored under multimodal elution conditions. All the enantiomeric mixtures of CDXs were enantioseparated with very high enantioselectivity and resolution with a and R-S ranging from 1.43 to 12.41 and from 1.48 to 10.29, respectively. The best performances were achieved on amylose tris-3,5-dimethylphenylcarbamate stationary phase under polar organic elution conditions. Furthermore the enantiomeric purity for all the CDXs was measured, achieving values higher than 99%. Based on the obtained results, the influence of the mobile phases and structural features of the CSPs and CDXs on chiral discrimination are also discussed.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 11