Constituents of Schisandra verruculosa and their cytotoxic effect on human cancer cell lines

• Tipo: Artigo em Revista Científica Internacional
• Data: 2006

Autores

Rujida Wilairat (Autor) Outra; Anake Kijjoa (Autor) ICBAS; Madalena Pinto (Autor) FFUP; Maria Sao Jose Nascimento (Autor) FFUP; Artur M S Silva (Autor) Outra; Graham Eaton (Autor) Outra; Werner Herz (Autor) Outra

Revista

Título: Pharmaceutical Biology

Vol. 44

Páginas: 411-415

ISSN: 1388-0209

Editora: Taylor & Francis

Indexação

ISI Web of Knowledge - 5 Citações

Scopus - 5 Citações

Classificação Científica

FOS: Ciências da engenharia e tecnologias > Engenharia médica

Outras Informações

ID Authenticus: P-004-HQ6

DOI: 10.1080/13880200600794105

Abstract (EN): 1,2-bis-(4-Hydroxy-3-methoxyphenyl)-3-hydroxypropan-1-one (evafolin B, 1), 1-(4-hydroxy-3-methoxyphenyl)-3-hydroxypropan-1-one (2), were isolated for the first time from the genus Schisandra, along with abscisic acid (3), 4-hydroxybenzaldehyde (4), 4-hydroxybenzoic acid (5), methyl 4-hydroxybenzoate (6), methyl 3,4-dihydroxybenzoate (7), and vanillic acid (8). All the compounds were evaluated for their antitumor, antiproliferative, and antioxidant activities. Only compound 7 exhibited moderate activity against three human cancer cell lines and human lymphocytic proliferation, as well as strong inhibitory activity for DPPH free radicals, only slightly less than ascorbic acid.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 5