Synthesis of a Natural Chalcone and Its Prenyl Analogs - Evaluation of Tumor Cell Growth-Inhibitory Activities, and Effects on Cell Cycle and Apoptosis

• Tipo: Artigo em Revista Científica Internacional
• Data: 2012

Autores

Marta P Neves (Autor) Outra; Raquel T Lima (Autor) Outra; Kanthima Choosang (Autor) Outra; Panee Pakkong (Autor) Outra; Maria de Sao Jose Nascimento (Autor) FFUP; Helena Vasconcelos, MH (Autor) FFUP; Madalena Pinto (Autor) FFUP; Artur M S Silva (Autor) Outra; Honorina Cidade (Autor) FFUP

Revista

Título: Chemistry and Biodiversity

Vol. 9

Páginas: 1133-1143

ISSN: 1612-1872

Editora: Wiley-Blackwell

Indexação

ISI Web of Knowledge - 22 Citações

Scopus - 24 Citações

Classificação Científica

FOS: Ciências exactas e naturais > Química

Outras Informações

ID Authenticus: P-002-9DJ

DOI: 10.1002/cbdv.201100190

Abstract (EN): Six prenyl (=3-methylbut-2-en-1-yl) chalcones (=1,3-diphenylprop-2-en-1-ones), 27, and one natural non-prenylated chalcone, 1, have been synthesized and evaluated for their in vitro growth-inhibitory activity against three human tumor cell lines. A pronounced dose-dependent growth-inhibitory effect was observed for all prenylated derivatives, except for 7. The chalcone possessing one prenyloxy group at C(2'), i.e., 2, was the most active derivative against the three human tumor cell lines (5.9<GI50<7.7 mu M). The majority of compounds caused an increase in percentage of apoptotic cells and/or they interfered with cell cycle distribution in the MCF-7 cell line.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 11