IMPACT: Integrated Multiprogram Platform for Analyses in ConTest

• Tipo: Artigo em Revista Científica Internacional
• Data: 2011

Autores

Emanuel Maldonado (Autor) Outra; Julien Y Dutheil (Autor) Outra; Rute R Da Fonseca (Autor) Outra; Vitor Vasconcelos (Autor) FCUP; Agostinho Antunes (Autor) FCUP

Revista

Título: Journal of Heredity

Vol. 102

Páginas: 366-369

ISSN: 0022-1503

Editora: Oxford University Press

Indexação

ISI Web of Knowledge - 2 Citações

Scopus - 2 Citações

Classificação Científica

FOS: Ciências exactas e naturais > Ciências da terra e ciências do ambiente

Outras Informações

ID Authenticus: P-002-S3C

DOI: 10.1093/jhered/esr003

Abstract (EN): In this paper, we introduce a new Graphical User Interface that estimates evolutionary rates on protein sequences by assessing changes in biochemical constraints. We describe IMPACT, a platform-independent (tested in Linux, Windows, and MacOS) easy to install software written in Java. IMPACT integrates the use of a built-in multiple sequence alignment editor, with programs that perform phylogenetic and protein structure analyses (ConTest, PhyML, ATV, and Jmol) allowing the user to quickly and efficiently perform evolutionary analyses on protein sequences, including the detection of selection (negative and positive) signatures at the amino acid scale, which can provide fundamental insight about species evolution and ecological fitness. IMPACT provides the user with a working platform that combines a number of bioinformatics tools and utilities in one place, transferring information directly among the various programs and therefore increasing the overall performance of evolutionary analyses on proteins.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 4