N-(2-carboxyethyl)chitosans: regioselective synthesis, characterisation and protolytic equilibria

• Tipo: Artigo em Revista Científica Internacional
• Data: 2003

Autores

Skorik, YA (Autor) Outra; Gomes, CAR (Autor) FCUP; Vasconcelos, MTSD (Autor) Outra; Yatluk, YG (Autor) Outra

Revista

Título: Carbohydrate Research

Vol. 338

Páginas: 271-276

ISSN: 0008-6215

Editora: Elsevier

Indexação

ISI Web of Knowledge - 66 Citações

Scopus - 74 Citações

Classificação Científica

FOS: Ciências exactas e naturais > Química

Outras Informações

ID Authenticus: P-000-HZ5

DOI: 10.1016/s0008-6215(02)00432-9

Abstract (EN): N-(2-Carboxyethyl)chitosans were obtained by reaction of low molecular weight chitosan with a low degree of acetylation and 3-halopropionic acids under mild alkaline media (pH 8-9, NaHCO3) at 60 degreesC. The chemical structure of the derivatives obtained was determined by H-1 and C-13 NMR spectroscopies. It was found that alkylation of chitosan by 3-halopropionic acids proceeds exclusively at the amino groups. The products obtained are described in terms of their degrees of carboxyethylation and ratio of mono-, di-substitution and free amine content. The protonation constants of amino and carboxylate groups of a series of N-(2-carboxyethyl)chitosans were determined by pH-titration at ionic strength 0.1 M KNO3 and 25 degreesC.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 6