Nickel induces apoptosis in human neutrophils

• Tipo: Artigo em Revista Científica Internacional
• Data: 2013

Autores

Marisa Freitas (Autor) Outra; Pedro Barcellos de Souza (Autor) Outra; Christina Barja Fidalgo (Autor) Outra; Eduarda Fernandes (Autor) FFUP

Revista

Título: Biometals

Vol. 26

Páginas: 13-21

ISSN: 0966-0844

Editora: Springer Nature

Indexação

ISI Web of Knowledge - 16 Citações

Scopus - 21 Citações

Classificação Científica

FOS: Ciências exactas e naturais > Ciências biológicas

Outras Informações

ID Authenticus: P-002-0VK

DOI: 10.1007/s10534-012-9590-2

Abstract (EN): Nickel is an ubiquitous transition metal that is industrially applied in many forms, which inevitably leads to a high degree of occupational and environmental exposure. Over-exposure to nickel can produce a variety of adverse effects on human health, including allergy and lung and nasal cancers. In the present study, it is demonstrated, for the first time, that nickel [(Ni(II)] (as a nickel nitrate salt) at concentrations that may be attained in vivo, induces neutrophils' apoptosis by the intrinsic pathway. The use of diphenyleneiodonium, a NADPH oxidase inhibitor, delayed Ni(II)-induced apoptosis, suggesting that NADPH oxidase-derived reactive oxygen species and subsequent signaling could contribute to this event. This is an important finding since increased apoptosis mediated by nickel may disrupt the physiological activities of neutrophils, with potential impact in its immunological and antimicrobial role.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 9