Antioxidant enzyme activity in mesenteric artery from DPSPX-Hypertensive rats

• Tipo: Artigo em Livro de Atas de Conferência Internacional
• Data: 2002

Autores

Sousa, T (Autor) Outra; Fernandes, E (Autor) FFUP; Morato, M (Autor) FFUP; Carvalho, F (Autor) FFUP; Albino Teixeira, A (Autor) FMUP

Ata de Conferência Internacional

Título: 22ND MEETING OF THE EUROPEAN SOCIETY FOR MICROCIRCULATION: MICROCIRCULATION AND VASCULAR BIOLOGY

Páginas: 267-270

22nd Meeting of the European-Society-for-Microcirculation

EXETER, ENGLAND, AUG 28-30, 2002

Indexação

ISI Web of Knowledge - 0 Citações

Classificação Científica

FOS: Ciências médicas e da saúde > Medicina clínica

Outras Informações

ID Authenticus: P-000-S9Y

Abstract (EN): DPSPX (1,3-dipropyl-8-sulfophenylxanthine) induces hypertension, vascular hypertrophy and hyperplasia and impaired endothelium dependent vasodilation. Since oxidative stress is linked with cardiovascular injury we aimed at evaluating if DPSPX induced-hypertension is accompanied by vascular modifications in enzymatic antioxidant defenses. Three groups of rats were evaluated: control, treated with DPSPX (90 mg.kg(-1).h(-1), i.p.) for 3 days and sacrificed on day 3; and treated with DPSPX (90 mg.kg(-1),h(-1), i.p.) for 7 days and sacrificed on day 15. DPSPX treatment for 3 days increased the activity of glutathione peroxidase, glutathione reductase and glutathione-S-transferase. We can conclude that DPSPX-induced hypertension is associated with an increase of the mesenteric artery enzymatic antioxidant defenses in the acute phase of hypertension.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 4