Challenges for Nerve Repair Using Chitosan-Siloxane Hybrid Porous Scaffolds

• Tipo: Outra Publicação em Revista Científica Internacional
• Data: 2014

Autores

Yuki Shirosaki (Autor) Outra; Satoshi Hayakawa (Autor) Outra; Akiyoshi Osaka (Autor) Outra; Lopes, MA (Autor) FEUP; Jose D Santos (Autor) FEUP; Stefano Geuna (Autor) Outra; Ana C Mauricio (Autor) Outra

Revista

Título: BioMed Research International

Vol. 2014

Páginas: 1-7

ISSN: 2314-6133

Editora: Hindawi

Indexação

ISI Web of Knowledge - 18 Citações

ISI Web of Science

Scopus - 15 Citações

Pubmed / Medline

Redalyc

Classificação Científica

FOS: Ciências médicas e da saúde > Outras ciências médicas

CORDIS: Ciências Tecnológicas > Engenharia > Engenharia de biomateriais

Outras Informações

ID Authenticus: P-009-Q5Z

DOI: 10.1155/2014/153808

Abstract (EN): The treatment of peripheral nerve injuries remains one of the greatest challenges of neurosurgery, as functional recover is rarely satisfactory in these patients. Recently, biodegradable nerve guides have shown great potential for enhancing nerve regeneration. A major advantage of these nerve guides is that no foreign material remains after the device has fulfilled its task, which spares a second surgical intervention. Recently, we studied peripheral nerve regeneration using chitosan-gamma-glycidoxypropyltrimethoxysilane (chitosan-GPTMS) porous hybrid membranes. In our studies, these porous membranes significantly improved nerve fiber regeneration and functional recovery in rat models of axonotmetic and neurotmetic sciatic nerve injuries. In particular, the number of regenerated myelinated nerve fibers and myelin thickness were significantly higher in rat treated with chitosan porous hybrid membranes, whether or not they were used in combination with mesenchymal stem cells isolated from the Wharton's jelly of the umbilical cord. In this review, we describe our findings on the use of chitosan-GPTMS hybrids for nerve regeneration.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 7