Hot spots-A review of the protein-protein interface determinant amino-acid residues

• Tipo: Outra Publicação em Revista Científica Internacional
• Data: 2007

Autores

Irina S Moreira (Autor) Outra; Pedro A Fernandes (Autor) FCUP; Maria J Ramos (Autor) FCUP

Revista

Título: Proteins: Structure, Function and Genetics

Vol. 68

Páginas: 803-812

ISSN: 0887-3585

Editora: Wiley-Blackwell

Indexação

ISI Web of Knowledge - 567 Citações

Scopus - 594 Citações

Classificação Científica

FOS: Ciências exactas e naturais > Ciências biológicas

Outras Informações

ID Authenticus: P-004-81C

DOI: 10.1002/prot.21396

Abstract (EN): Proteins tendency to bind to one another in a highly specific manner forming stable complexes is fundamental to all biological processes. A better understanding of complex formation has many practical applications, which include the rational design of new therapeutic agents, and the analysis of metabolic and sig. nal transduction networks. Alanine-scan ning mutagene sis made possible the detection of the functional epitopes, and demonstrated that most of the protein-protein binding energy is related only to a group of few amino acids at intermolecular protein interfaces: the hot spots. The scope of this review is to summarize all the available information regarding hot spots for a better atomic understanding of their structure and function. The ultimate objective is to improve the rational design of complexes of high affinity and specificity as well as that Of small molecules, which can mimic the functional epitopes of the proteic complexes.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 10