Chromone: A valid scaffold in medicinal chemistry

• Tipo: Artigo em Revista Científica Internacional
• Data: 2014

Autores

gaspar, am (Autor) Outra; matos, mj (Autor) Outra; garrido, jmpj (Autor) Outra; uriarte, e (Autor) Outra; borges, ffm (Autor) FCUP

Revista

Título: Chemical Reviews

Vol. 114

Páginas: 4960-4992

ISSN: 0009-2665

Editora: American Chemical Society

Indexação

ISI Web of Knowledge - 577 Citações

Scopus - 587 Citações

Classificação Científica

FOS: Ciências exactas e naturais > Química

CORDIS: Ciências Físicas > Química > Química aplicada > Química farmacêutica

Outras Informações

ID Authenticus: P-009-CX4

DOI: 10.1021/cr400265z

Abstract (EN): Simple chromones, a group of heterocyclic compounds, have been studied as a fruitful approach in medicinal chemistry and consequently, with value as a privileged scaffold. The main classic routes for the obtention of simple chromones from ortho-hydroxyarylalkylketones enclose three synthetic approaches, synthesis via Claisen condensation (classic Claisen condensation, Baker-Venkatamaran, and Kostanecki-Robinson reaction), synthesis via benzopyrylium salts and via Vilsmeier-Haack reaction. Chromones can be obtained by the reaction of a phenol with acetylenic dicarboxylic acids or esters or with chlorofumaric acid, or other analogues, in basic conditions, such as metallic sodium. Heterocyclic-substituted chromones are probably one of the most representative derivatives as these types of entities are very important as ligands in the medicinal chemistry artwork. It is expected that the research performed with type of compounds will uncover further interesting aspects in the medicinal field.

Idioma: Inglês

Tipo (Avaliação Docente): Científica