Antioxidant therapy: Still in search of the 'magic bullet'

• Tipo: Artigo em Revista Científica Internacional
• Data: 2013

Autores

benfeito, sofia (Autor) Outra; oliveira, catarina (Autor) Outra; soares, pedro (Autor) Outra; fernandes, carlos (Autor) Outra; silva, tiago (Autor) Outra; teixeira, jose (Autor) Outra; borges, fernanda (Autor) FCUP

Revista

Título: Mitochondrion

Vol. 13

Páginas: 427-435

ISSN: 1567-7249

Editora: Elsevier

Indexação

ISI Web of Knowledge - 39 Citações

Scopus - 46 Citações

Classificação Científica

FOS: Ciências exactas e naturais > Química

CORDIS: Ciências Físicas > Química > Química aplicada > Química farmacêutica

Outras Informações

ID Authenticus: P-006-7NF

DOI: 10.1016/j.mito.2012.12.002

Abstract (EN): The therapeutic potential of natural phenolic antioxidants in human diseases associated with oxidative damage has received great attention to date. Appraisal of literature evidences that, in general, antioxidant therapy has enjoyed relative successes in preclinical studies but little benefits in human intervention studies or clinical trials. In fact, despite the huge, largely untapped potential therapeutic benefit of natural phenolic antioxidants, such as vitamins, non-flavonoid and flavonoid compounds, they appear not to be suitable drug candidates. The problem may be related, among others, to their non-drug-likeness properties. Though controversial the results obtained so far confirm the importance of exploring phenolic natural systems as safe templates for the design of new antioxidants. To support the assumption an outlook of the lead structural optimization process to improve ADME properties was given by means of natural hydroxycinnamic acids as a case study. The optimization of drug physicochemical properties and the development of appropriate delivery antioxidant systems can provide in the next future a way out to attain effective therapeutic antioxidant agents. (C) 2012 Elsevier B.V. and Mitochondria Research Society. All rights reserved.

Idioma: Inglês

Tipo (Avaliação Docente): Científica