Voltammetric quantification of fluoxetine: Application to quality control and quality assurance processes

• Tipo: Artigo em Revista Científica Internacional
• Data: 2006

Autores

lencastre, rui p. (Autor) Outra; matos, cristina d. (Autor) Outra; garrido, jorge (Autor) Outra; borges, fernanda (Autor) FFUP; garrido, e. manuela (Autor) Outra

Revista

Título: Journal of Food and Drug Analysis

Vol. 14

Páginas: 242-246

ISSN: 1021-9498

Editora: Elsevier

Indexação

ISI Web of Knowledge - 27 Citações

Scopus - 29 Citações

Classificação Científica

FOS: Ciências exactas e naturais > Química

CORDIS: Ciências Físicas > Química

Outras Informações

ID Authenticus: P-004-HKK

Abstract (EN): The oxidative behaviour of fluoxetine was studied at a glassy carbon electrode in various buffer systems and at different pH using cyclic, differential pulse and square wave voltammetry. A new square wave voltammetric method suitable for the quality control of fluoxetine in commercial formulations has been developed using a borate pH 9 buffer solution as supporting electrolyte. Under optimized conditions, a linear response was obtained in the range 10 to 16 mu M with a detection limit of 1.0 mu M. Validation parameters such as sensitivity, precision and accuracy were evaluated. The proposed method was successfully applied to the determination of fluoxetine in pharmaceutical formulations. The results were statistically compared with those obtained by the reference high-performance liquid chromatographic method. No significant differences were found between the methods.

Idioma: Inglês

Tipo (Avaliação Docente): Científica