Antioxidant versus cytotoxic properties of hydroxycinnamic acid derivatives - A new paradigm in phenolic research

• Tipo: Artigo em Revista Científica Internacional
• Data: 2008

Autores

Mario Esteves (Autor) Outra; Christophe Siquet (Autor) FEUP; Alexandra Gaspar (Autor) Outra; Vitor Rio (Autor) Outra; Joana B Sousa (Autor) Outra; Salette Reis (Autor) FFUP; Maria P M Marques (Autor) Outra; Fernanda Borges (Autor) FFUP

Revista

Título: Archiv der Pharmazie

Vol. 341 Nº 3

Páginas: 164-173

ISSN: 0365-6233

Editora: Wiley-Blackwell

Indexação

ISI Web of Knowledge - 46 Citações

Scopus - 48 Citações

Classificação Científica

FOS: Ciências exactas e naturais > Química

Outras Informações

ID Authenticus: P-004-0ZW

DOI: 10.1002/ardp.200700168

Abstract (EN): Trihydroxycinnamic derivatives were synthesized and evaluated for their antioxidant and cytotoxic activities. The ester derivatives exhibited a higher radical-scavenging activity, when liposomes were used as target systems, a fact which may be related to their lipophilicity and conformational preferences. These compounds were found to display significant growth inhibition and cytotoxic effects towards a human cervix adenocarcinoma cell line (Hel,a). The partition coefficients presently obtained for the trihydroxycinnamic derivatives correlate well both with their structural characteristics and with their antioxidant/cytotoxic activities. A positive structure-activity-property relationship between cytotoxic and antioxidant activities, which is intrinsically related with physico-chemical and conformational properties, is anticipated, as a noteworthy study that must be done for phenolic systems. As damage events are frequently correlated with oxidative stress, the prevalence of both properties in a single compound could be beneficial in terms of rationale preventive or therapeutic purposes.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 10