Novel carbocyclic nucleosides containing a cyclobutyl ring. Guanosine and adenosine analogues

• Tipo: Artigo em Revista Científica Internacional
• Data: 1998

Autores

Borges, JER (Autor) Outra; Fernandez, F (Autor) Outra; Garcia, X (Autor) Outra; Hergueta, AR (Autor) Outra; Lopez, C (Autor) Outra; Andrei, G (Autor) Outra; Snoeck, R (Autor) Outra; Witvrounw, M (Autor) Outra; Balzarini, J (Autor) Outra; De Clercq, E (Autor) Outra

Revista

Título: Nucleosides, Nucleotides and Nucleic Acids

Vol. 17

Páginas: 1237-1253

ISSN: 1525-7770

Editora: Taylor & Francis

Indexação

ISI Web of Knowledge - 12 Citações

Scopus - 13 Citações

Classificação Científica

FOS: Ciências exactas e naturais > Ciências biológicas

Outras Informações

ID Authenticus: P-00G-9Q1

DOI: 10.1080/07328319808004236

Abstract (EN): (1R,cis)-2-(3-Amino-2,2-dimethylcyclobutyl)ethanol (4) was used as a precursor in the synthesis of cyclobutyl nucleoside analogues containing guanine, 8-azaguanine, adenine or 8-azaadenine. All the compounds were evaluated as antiviral agents in a variety of assay systems. Some activity was noted for compound 13, 17, 19 and 20 against vaccinia virus and for compounds 11, 12, 13, 17, 19 and 20 against herpes simplex virus, at concentrations that were up to 10-fold below the cytotoxic concentrations for the host cells.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 17