Synthesis, characterization and antibacterial studies of a copper(II) lomefloxacin ternary complex

• Tipo: Artigo em Revista Científica Internacional
• Data: 2014

Autores

Patricia Fernandes (Autor) Outra; Isabel Sousa (Autor) Outra; Luis Cunha Silva (Autor) Outra; Mariana Ferreira (Autor) Outra; Baltazar de Castro (Autor) FCUP; Eulalia F Pereira (Autor) FCUP; Maria J Feio (Autor) Outra; Paula Gameiro (Autor) FCUP

Revista

Título: Journal of Inorganic Biochemistry

Vol. 131

Páginas: 21-29

ISSN: 0162-0134

Editora: Elsevier

Indexação

ISI Web of Knowledge - 44 Citações

Scopus - 44 Citações

Classificação Científica

FOS: Ciências exactas e naturais > Química

Outras Informações

ID Authenticus: P-008-GSV

DOI: 10.1016/j.jinorgbio.2013.10.013

Abstract (EN): Solution behavior of lomefloxacin (lmx) complexes with copper(II) in the presence and absence of 1,10-phenanthroline (phen) was studied in aqueous solution, by potentiometry. The results obtained showed that under physiological conditions (micromolar concentration range and pH 7.4) only copper(II):lmx:phen ternary complexes are stable. Hence, a novel copper(II) ternary complex of lomefloxacin with the nitrogen donor heterocyclic ligand phen was synthesized and characterized by means of UV-visible and IR spectroscopy, elemental analysis and X-ray crystallography. In the synthesized complex (1), [Cu(lmx)(phen)(NO3)]center dot 5H(2)O, lmx acts as a bidentate ligand coordinating the metal cation, in its anionic form, through the carbonyl and carboxyl oxygens and phen coordinates through two N-atoms forming the equatorial plane of a distorted square-pyramidal geometry. The fifth ligand of the penta-coordinated Cu(II) center is occupied axially by an oxygen atom from the nitrate ion. Minimum inhibitory concentration (MIC) determinations of the complex and comparison with free lomefloxacin in various E. coli strains indicated that the Cu-complex is an antimicrobial which is as efficient as the free antibiotic but strongly suggest that the cell intake route of both species is different. Moreover, spectrophotometric stability studies suggest that the solution of the complex synthesized is considerably more photostable than the free fluoroquinolone supporting, therefore, the complex's suitability as a candidate for further biological testing in fluoroquinolone-resistant microorganisms with possible reduced side-effects.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 9