Solution studies on binary and ternary complexes of copper(II) with some fluoroquinolones and 1,10-phenanthroline: Antimicrobial activity of ternary metalloantibiotics

• Tipo: Artigo em Revista Científica Internacional
• Data: 2007

Autores

Paula Gameiro (Autor) FCUP; Catarina Rodrigues (Autor) Outra; Teresa Baptista (Autor) Outra; Isabel Sousa (Autor) Outra; Baltazar de Castro (Autor) FCUP

Revista

Título: International Journal of Pharmaceutics

Vol. 334

Páginas: 129-136

ISSN: 0378-5173

Editora: Elsevier

Indexação

ISI Web of Knowledge - 38 Citações

Scopus - 40 Citações

Classificação Científica

FOS: Ciências médicas e da saúde > Medicina básica

Outras Informações

ID Authenticus: P-004-ANX

DOI: 10.1016/j.ijpharm.2006.10.035

Abstract (EN): Interaction of norfloxacin and ofloxacin with copper(II) and copper(II)/phenanthroline has been studied in aqueous solution and the stability constants of the binary complexes Cu(II)/fluoroquinolone and of the ternary complexes Cu(II)/phenanthroline/fluoroquinolone have been determined by potentiometry and UV-vis spectrophotometry. The stability constants for the binary and ternary complexes of norfloxacin were always higher than those found for ofloxacin and comparing the values obtained for the binary and ternary species (Delta log K) it is possible to conclude that the ternary complexes are more stable than the binary ones, suggesting that an interaction occurs between the ligands in the ternary complexes. From the distribution diagrams it is possible to state that at physiological pH 7.4, the copper ternary complexes, are the main species in solution not only at the concentration used to determined the stability constants but also at the minimum inhibitory concentration. The antibacterial activity of these complexes, in different bacterial strains, was determined, at physiological pH, and the results obtain show that these ternary complexes may be good candidates as metalloantibiotics.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 8