Acid/base properties of beta-blockers and benzodiazepines in sodium dodecyl sulfate micelles. A spectrophotometric and potentiometric study

• Tipo: Artigo em Revista Científica Internacional
• Data: 1998

Autores

de Castro, B (Autor) FCUP; Gameiro, P (Autor) FCUP; Guimaraes, C (Autor) Outra; Lima, JLFC (Autor) FFUP; Reis, S (Autor) FFUP

Revista

Título: Journal of Pharmaceutical Sciences

Vol. 87

Páginas: 356-359

ISSN: 0022-3549

Editora: Elsevier

Indexação

ISI Web of Knowledge - 10 Citações

Scopus - 22 Citações

Classificação Científica

FOS: Ciências exactas e naturais > Química

Outras Informações

ID Authenticus: P-001-8CR

DOI: 10.1021/js970219k

Abstract (EN): The effect of sodium dodecyl sulfate (SDS) micelles on the acid-base properties of two family of pharmaceutical drugs (beta-blockers and benzodiazepines) at 25 degrees C and I = 0.1 M NaCl have been studied. The characterization of the several solution equilibria for the system drug/SDS micelle solution was performed by potentiometry and spectrophotometry, below and above the critical micelle concentration (cmc). Two widely used models have been applied to quantify the effect of micelles on the pK(a) of the drugs, and the results obtained point to different interactions of each family of drugs with the micelles.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 4