N-Cinnamoylated Aminoquinolines as Promising Antileishmanial Agents

• Tipo: Artigo em Revista Científica Internacional
• Data: 2013

Autores

Vale Costa, S (Autor) Outra; Costa Gouveia, J (Autor) Outra; Perez, B (Autor) Outra; Silva, T (Autor) Outra; Teixeira, C (Autor) Outra; Gomes, P (Autor) FCUP; Gomes, MS (Autor) ICBAS

Revista

Título: Antimicrobial Agents and Chemotherapy

Vol. 57

Páginas: 5112-5115

ISSN: 0066-4804

Editora: American Society for Microbiology

Indexação

ISI Web of Knowledge - 13 Citações

Scopus - 13 Citações

Classificação Científica

FOS: Ciências médicas e da saúde > Medicina básica

Outras Informações

ID Authenticus: P-006-6Z9

DOI: 10.1128/aac.00557-13

Abstract (EN): A series of cinnamic acid conjugates of primaquine and chloroquine were evaluated for their in vitro antileishmanial activities. Although primaquine derivatives had modest activity, chloroquine conjugates exhibited potent activity against both promastigotes (50% inhibitory concentration [IC50] = 2.6 to 21.8 mu M) and intramacrophagic amastigotes (IC50 = 1.2 to 9.3 mu M) of Leishmania infantum. Both the high activity of these chloroquine analogues and their mild-to-low toxicity toward host cells make them promising leads for the discovery of new antileishmanial agents.

Idioma: Inglês

Tipo (Avaliação Docente): Científica