Mycobacteria-induced anaemia revisited: A molecular approach reveals the involvement of NRAMP1 and lipocalin-2, but not of hepcidin

• Tipo: Artigo em Revista Científica Internacional
• Data: 2011

Autores

Pedro N Rodrigues (Autor) ICBAS; Sandro S Gomes (Autor) Outra; Joao V Neves (Autor) Outra; Sandra Gomes Pereira (Autor) Outra; Margarida Correia Neves (Autor) Outra; Claudio Nunes Alves (Autor) Outra; Jens Stolte (Autor) Outra; Mayka Sanchez (Autor) Outra; Rui Appelberg (Autor) ICBAS; Martina U Muckenthaler (Autor) Outra; Salome Gomes, MS (Autor) ICBAS

Revista

Título: Immunobiology

Vol. 216

Páginas: 1127-1134

ISSN: 0171-2985

Editora: Elsevier

Indexação

ISI Web of Knowledge - 22 Citações

Scopus - 24 Citações

Pubmed / Medline

Classificação Científica

FOS: Ciências médicas e da saúde > Medicina básica

CORDIS: Ciências da Saúde > Ciências Médicas

Outras Informações

ID Authenticus: P-002-KW5

DOI: 10.1016/j.imbio.2011.04.004

Abstract (EN): Anaemia is a frequent complication of chronic infectious diseases but the exact mechanisms by which it develops remain to be clarified. In the present work, we used a mouse model of mycobacterial infection to study molecular alterations of iron metabolism induced by infection. We show that four weeks after infection with Mycobacterium avium BALB/c mice exhibited a moderate anaemia, which was not accompanied by an increase on hepatic hepcidin mRNA expression. Instead, infected mice presented increased mRNA expression of ferroportin (SIc40a1), ceruloplasmin (Cp), hemopexin (Hpx), heme-oxygenase-1 (Hmox1) and lipocalin-2 (Lcn2). Both the anaemia and the mRNA expression changes of iron-related genes were largely absent in C.D2 mice which bear a functional allele of the Nramp1 gene. Data presented in this work suggest that anaemia due to a chronic mycobacterial infection may develop in the absence of elevated hepcidin expression, is influenced by Nramp1 and may involve lipocalin-2.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 8