Influence of Catechol-O-Methyltransferase (COMT) Genotypes on the Prognosis of Canine Mammary Tumors

• Tipo: Artigo em Revista Científica Internacional
• Data: 2009

Autores

Dias D Pereira (Autor) Outra; Lopes, CC (Autor) Outra; Matos, AJF (Autor) ICBAS; Pinto, D (Autor) Outra; Gaertner, F (Autor) Outra; Lopes, C (Autor) ICBAS; Medeiros, R (Autor) ICBAS

Revista

Título: Veterinary Pathology

Vol. 46 Nº 46

Páginas: 1270-1274

ISSN: 0300-9858

Editora: SAGE

Indexação

ISI Web of Knowledge - 6 Citações

Scopus - 9 Citações

Pubmed / Medline

Classificação Científica

FOS: Ciências agrárias > Ciências veterinárias

Outras Informações

ID Authenticus: P-003-EYP

DOI: 10.1354/vp.08-vp-0298-d-fl

Abstract (EN): Catechol-O-methyltransferase (COMT) is an important enzyme involved in inactivation of catechol estrogens, which are metabolites with carcinogenic properties. Some investigations in human breast cancer associate a genetic polymorphism in the COMT gene (COMT val158met) with an increased risk and poor clinical progression of the disease. In dogs, there are 2 recognized single nucleotide polymorphisms in the COMT gene (COMTG216A and COMTG482A); however, their influence on the outcome of mammary neoplasms has never been investigated. The purpose of this study is to investigate the influence of COMT in the clinical progression of canine mammary tumors, namely in recurrence, metastasis and survival by testing 2 SNPs (G216A and G482A), and 2 genotypes of the COMT gene. A case series was conducted analyzing genomic DNA samples by polymerase chain reaction-restriction fragment length polymorphism from 80 bitches with mammary tumors. Animals were Submitted to an active follow-up study for a period of 24 months after surgery. We observed that bitches carrying both genetic variations simultaneously are more likely to develop recurrence of mammary lesions. Our results demonstrate a possible role for COMT genotypes in the outcome of mammary neoplasms in the dog. Identifying a genetic factor predictive of recurrence may be useful in selecting the most effective surgical approach for canine mammary neoplasms.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 5