Expression of E-cadherin in normal, hyperplastic and neoplastic feline mammary tissue

• Tipo: Artigo em Revista Científica Internacional
• Data: 2003

Autores

Patricia Dias Pereira (Autor) ICBAS; Fátima Gartner (Autor) ICBAS

Revista

Título: Veterinary Record

Vol. 153

Páginas: 297-302

ISSN: 0042-4900

Editora: Wiley-Blackwell

Indexação

Pubmed / Medline

Classificação Científica

FOS: Ciências agrárias > Ciências veterinárias

Outras Informações

ID Authenticus: P-000-F63

Abstract (EN): This paper describes an immunohistochemical study of the expression of E-cadherin in four samples of normal, eight samples of hyperplastic and 19 samples of neoplastic feline mammary tissue. In the normal tissues, the luminal epithelial cells showed a strong pattern of staining for E-cadherin at the cell-cell boundaries, whereas the myoepithelium showed no immunoreactivity. In the hyperplastic tissues and the five benign neoplasms, there were disturbances in the expression of E-cadherin in the luminal epithelium, in the form of the coexistence of membranous and cytoplasmic staining, together with immunoreactivity in a small percentage of myoepithelial cells. In 11 of 14 carcinomas, there was a reduction or absence of E-cadherin expression and abnormalities in the pattern of immunostaining; these changes were more pronounced in cribriform and solid carcinomas.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 10