Secretory carcinoma of the canine mammary gland

• Tipo: Artigo em Revista Científica Internacional
• Data: 1999

Autores

Cassali, GD (Autor) Outra; Gobbi, H (Autor) Outra; Fátima Gärtner (Autor) ICBAS; Fernando Schmitt (Autor) Outra

Revista

Título: Veterinary Pathology

Vol. 36

Páginas: 601-603

ISSN: 0300-9858

Editora: SAGE

Indexação

ISI Web of Knowledge - 8 Citações

Scopus - 12 Citações

Pubmed / Medline

Classificação Científica

FOS: Ciências agrárias > Outras ciências agrárias

Outras Informações

ID Authenticus: P-008-P5R

DOI: 10.1354/vp.36-6-601

Abstract (EN): Secretory carcinoma is an uncommon variant of breast cancer, characterized by the presence of intracellular and extracellular eosinophilic secretion. Here, we report the cytologic, histologic, and immunohistochemical findings of a secretory carcinoma diagnosed in the left inguinal mammary gland of a 3-year-old female German Shepherd Dog. The fine-needle aspiration cytology showed numerous large branching sheets of neoplastic cells and isolated cells with cytoplasmic vacuoles. Histologically, the tumor was composed of cells with clear cytoplasm and prominent vacuoles that pushed the nuclei to the periphery, resembling signet ring cells. These cells were arranged in solid or tubular structures with lumenal spaces filled with eosinophilic secretion. Immunohistochemical reactions to cytokeratin (CAM 5.2) and alpha-lactalbumin were strongly positive in all neoplastic cells, and staining for vimentin and S100 protein was negative. The cytomorphologic and immunohistochemical features of this tumor are similar to those seen in tumors in women, hence enabling the diagnosis of a rare case of primary secretory carcinoma of the canine mammary gland.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 3