Circulating DNA: Diagnostic Tool and Predictive Marker for Overall Survival of NSCLC Patients

• Tipo: Artigo em Revista Científica Internacional
• Data: 2012

Autores

Raquel Catarino (Autor) Outra; Ana Coelho (Autor) Outra; Antonio Araujo (Autor) Outra; Monica Gomes (Autor) Outra; Augusto Nogueira (Autor) Outra; Carlos Lopes (Autor) Outra; Rui Medeiros (Autor) ICBAS

Revista

Título: PLoS ONE

Vol. 7 Nº 4

Página Final: e38559

ISSN: 1932-6203

Editora: Public Library of Science

Indexação

ISI Web of Knowledge - 55 Citações

Scopus - 54 Citações

Pubmed / Medline

Classificação Científica

CORDIS: Ciências da Saúde

Outras Informações

ID Authenticus: P-002-90E

DOI: 10.1371/journal.pone.0038559

Resumo (PT): PURPOSE: The purpose of our study was to determine whether the amounts of circulating DNA (cDNA) could discriminate between NSCLC patients and healthy individuals and assess its value as a prognostic marker of this disease. METHODS: We conducted a study of 309 individuals and the cDNA levels were assessed through real-time PCR methodology. RESULTS: We found increased cDNA levels in NSCLC patients compared to control individuals. We also found a decreased overall survival time in patients presenting high cDNA levels, when compared to lower cDNA concentrations. CONCLUSIONS: Quantification of cDNA may be a good tool for NSCLC detection with potential for clinical applicability.

Abstract (EN): Purpose: The purpose of our study was to determine whether the amounts of circulating DNA (cDNA) could discriminate between NSCLC patients and healthy individuals and assess its value as a prognostic marker of this disease. Methods: We conducted a study of 309 individuals and the cDNA levels were assessed through real-time PCR methodology. Results: We found increased cDNA levels in NSCLC patients compared to control individuals. We also found a decreased overall survival time in patients presenting high cDNA levels, when compared to lower cDNA concentrations. Conclusions: Quantification of cDNA may be a good tool for NSCLC detection with potential for clinical applicability.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 8