Ras gene in marine mussels: A molecular level response to petrochemical exposure

• Tipo: Artigo em Revista Científica Internacional
• Data: 2008

Autores

Lima, I (Autor) Outra; Peck, MR (Autor) Outra; Rendon Von Osten, J (Autor) Outra; Soares, AMM (Autor) Outra; Guilhermino, L. (Autor) ICBAS; Rotchell, JM (Autor) Outra

Revista

Título: Marine Pollution Bulletin

Vol. 56

Páginas: 633-640

ISSN: 0025-326X

Editora: Elsevier

Indexação

ISI Web of Knowledge - 9 Citações

ISI Web of Science

Scopus - 8 Citações

Pubmed / Medline

Classificação Científica

FOS: Ciências exactas e naturais > Ciências biológicas

Outras Informações

ID Authenticus: P-004-0MY

DOI: 10.1016/j.marpolbul.2008.01.018

Abstract (EN): Mussels are susceptible to numerous toxicants and are often employed as bioindicators. This study investigated the status of the ras proto-oncogene in Mytilus galloprovincialis following petrochemical exposure. A M. galloprovincialis homologue of the vertebrate ras gene was isolated, showing conserved sequence in regions of functional importance and a high incidence of polymorphic variation. Mutational damage was investigated in mussels chronically exposed to the water-accommodated fraction of #4 fuel-oil (WAF), and in mussels collected along the NW coast of Portugal in sites with different levels of petrochemical contamination. A ras gene point mutation was identified in the codon 35 of one individual exposed to 12.5% WAF No mutations were detected in mussels from the WAF control or environmental samples. This represents the first report of a ras gene mutation, experimentally-induced by petrochemical exposure, in an invertebrate species.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 8