Cardiac, skeletal, and smooth muscle regulation by ghrelin

• Tipo: Artigo em Revista Científica Internacional
• Data: 2008

Autores

Leite-Moreira, AF (Autor) FMUP; Henriques-Coelho, T (Autor) FMUP; Rocha-Sousa, A (Autor) FMUP

Revista

Título: Vitamins and Hormones

Páginas: 207-238

ISSN: 0083-6729

Editora: Elsevier

Indexação

ISI Web of Science

Pubmed / Medline

Classificação Científica

FOS: Ciências médicas e da saúde

Outras Informações

Abstract (EN): Ghrelin, mainly secreted from gastric mucosa, is the endogenous ligand for the growth hormone secretagogue receptor and induces a potent release of growth hormone. Ghrelin is widely expressed in different tissues and therefore has both endocrine and paracrine/autocrine effects. In this chapter, we summarize: (1) structure and distribution of ghrelin and its receptors; (2) myocardial effects of ghrelin, describing its acute and chronic actions on cardiac function; (3) ghrelin effects on smooth muscle, namely vascular smooth muscle, intraocular and gastrointestinal smooth muscle; and (4) skeletal actions of ghrelin. Ghrelin has a potent vasodilator effect, thereby reducing cardiac afterload and increasing cardiac output. In models of heart failure and myocardial ischemia, ghrelin administration has beneficial effects. At smooth muscle, ghrelin modulates vascular tone, increases gut transit, and relaxes iris muscles. In the skeletal muscle, ghrelin regulates resting membrane potential. In conclusion, there are increasing evidences that ghrelin is a peptide with paracrine actions that can modulate cardiac, smooth, and skeletal muscle functions.

Idioma: Inglês

Tipo (Avaliação Docente): Científica