Nonpigmented fixed drug eruption induced by esomeprazole

• Tipo: Artigo em Revista Científica Internacional
• Data: 2010

Autores

Morais P (Autor) FMUP; Baudrier T (Autor) Outra; Mota A (Autor) FMUP; Cunha AP (Autor) Outra; Cadinha S (Autor) Outra; Barros AM (Autor) Outra

Revista

Título: Cutaneous and Ocular Toxicology

Vol. 29 Nº 3

Páginas: 217-220

ISSN: 1556-9527

Editora: Taylor & Francis

Indexação

ISI Web of Knowledge - 11 Citações

Scopus - 15 Citações

Classificação Científica

FOS: Ciências médicas e da saúde > Medicina clínica

Outras Informações

ID Authenticus: P-003-37B

DOI: 10.3109/15569527.2010.484824

Abstract (EN): A 56-year-old white woman developed a distinctive skin eruption over her mammary, lumbosacral, and pubic areas 2 weeks after the start of esomeprazole therapy for dyspeptic symptoms. Skin biopsy disclosed a spongiotic dermatitis with predominantly lymphocytic dermal infiltrate. Treatment with a tapering dose of corticosteroid and withdrawal of the suspected drug led to a rapid resolution of the eruption without residual dyschromia. Patch testing with esomeprazole 2% in petrolatum was negative at 48 and 72 hours but became positive on day 6. Oral-controlled provocation test induced the reappearance of the lesions over the mammary areas, confirming the putative involvement of this drug. Therefore, the patient was diagnosed as having a nonpigmented fixed drug eruption associated with esomeprazole. This compound is a proton-pump inhibitor developed as the S-isomer of omeprazole to improve its pharmacokinetic properties. Reports of cutaneous reactions to proton-pump inhibitors are quite common, but reports of such reactions to esomeprazole are rare, which demonstrates the need for higher clinical awareness and knowledge of reactions to these drugs.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 4