Beat-to-beat modulation of right and left ventricular positive dP/dt by afterload Implications for the evaluation of inotropy

• Tipo: Artigo em Revista Científica Internacional
• Data: 2003

Autores

Correia-Pinto, J (Autor) Outra; Leite-Moreira, AF (Autor) FMUP; Henriques-Coelho, T (Autor) FMUP; Magalhães, S (Autor) Outra; Gillbert, TC (Autor) Outra

Revista

Título: Acta Cardiologica

Vol. 58 Nº 4

Páginas: 327-334

ISSN: 0001-5385

Editora: Taylor & Francis

Indexação

ISI Web of Knowledge - 2 Citações

ISI Web of Science

Scopus - 2 Citações

Pubmed / Medline

Classificação Científica

FOS: Ciências médicas e da saúde

Outras Informações

ID Authenticus: P-000-FK9

DOI: 10.2143/ac.58.4.2005290

Abstract (EN): Objectives - The rate of pressure rise (dP/dt(max)) has mainly been studied in the left ventricle (LV), where it was demonstrated to be highly dependent of preload, but independent of afterload. Load dependence of right ventricular (RV) dP/dt(max) is assumed to be similar to (LV)dP/dt(max), although this issue has not yet been investigated in detail. In the current study, we evaluated acute afterload dependence of dP/dt(max) in both ventricles in rats. Methods and results - Adult Wistar rats (n = 8) were instrumented to record RV and W pressures and septal-free wall diameters. RV and W afterload elevations were performed by beat-to-beat graded constrictions of the pulmonary trunk or aortic root, respectively. Control cycles and low, moderate and high (isovolumetric) afterload levels were analysed. In both ventricles, afterload modulation of dP/dt was assessed by dP/dt(max) normalized for end-diastolic dimensions (dP/dt(max)/EDD) and by peak and mean accelerations of pressure rise. RV afterload elevation increased dP/dt(max), dP/dt(max)/EDD, peak and mean acceleration of RV pressure rise, without changing the time from end-diastole to dP/dt(max). LV afterload elevations did not significantly change the corresponding left-sided parameters. Conclusions - In this study we demonstrated that, in contrast to the left ventricle, right ventricular dP/dt(max) and dP/dt(max)/EDD relation are significantly afterload sensitive. This should be taken into account for its application in the haemodynamic evaluation of cardiac function in experimental and clinical settings.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 10