Importance of TP53 codon 72 and intron 3 duplication 16bp polymorphisms in prediction of susceptibility on breast cancer

• Tipo: Artigo em Revista Científica Internacional
• Data: 2008

Autores

Sandra Costa (Autor) Outra; Daniela Pinto (Autor) Outra; Deolinda Pereira (Autor) Outra; Helena Rodrigues (Autor) Outra; Jorge Cameselle Teijeiro (Autor) Outra; Rui Medeiros (Autor) ICBAS; Fernando Schmitt (Autor) FMUP

Revista

Título: BMC Cancer

Vol. 8 Nº 10

Página Final: 32

ISSN: 1471-2407

Editora: Springer Nature

Indexação

ISI Web of Knowledge - 83 Citações

Scopus - 91 Citações

Pubmed / Medline

Classificação Científica

FOS: Ciências médicas e da saúde > Medicina clínica

CORDIS: Ciências da Saúde > Ciências Médicas > Medicina > Anatomia patológica

Outras Informações

ID Authenticus: P-004-203

DOI: 10.1186/1471-2407-8-32

Abstract (EN): Background: TP53 is one of major tumour suppressor genes being essential in preservation of genome integrity. Two very common polymorphisms have been demonstrated to contribute to cancer susceptibility and tumour behaviour. The purpose of this study was to evaluate the role of Arg72Pro and PIN3 Ins16bp polymorphisms in TP53 gene as genetic susceptibility and predictive markers to breast cancer. Methods: We analysed DNA samples from 264 breast cancer patients and 440 controls, for TP53 Arg72Pro and PIN3 Ins16bp polymorphisms using PCR-RFLP. Results: We observed that women with A2A2 genotype have increased risk for developing breast cancer, either in women with or without familial history (FH) of the disease (OR = 4.40, 95% CI 1.60 - 12.0; p=0.004; OR=3.88, 95% CI 1.18 - 12.8; p=0.026, respectively). In haplotype analysis, statistically significant differences were found between TP53 Arg-A2 haplotype frequencies and familial breast cancer cases and the respective control group ( OR=2.10, 95% CI 1.08 - 4.06; p=0.028). Furthermore, both TP53 polymorphisms are associated with higher incidence of lymph node metastases. Conclusion: Our findings suggest TP53 PIN3 Ins16bp polymorphism as a real risk modifier in breast cancer disease, either in sporadic and familial breast cancer. Furthermore, both TP53 polymorphisms are associated with higher incidence of lymph node metastases.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 7