The association between the 4G/5G polymorphism in the promoter of the plasminogen activator inhibitor-1 gene and deep venous thrombosis in young people

• Tipo: Artigo em Revista Científica Internacional
• Data: 2005

Autores

Mansilha A. (Autor) FMUP; Araújo F. (Autor) FMUP; Severo M. (Autor) FMUP; Sampaio S. (Autor) FMUP; Toledo T. (Autor) Outra; Henriques I. (Autor) Outra; Roncon Albuquerque R. (Autor) FMUP

Revista

Título: Phlebology

Vol. 20 Nº 1

Páginas: 48-52

ISSN: 0268-3555

Editora: SAGE

Indexação

Pubmed / Medline

Classificação Científica

CORDIS: Ciências da Saúde > Ciências Médicas > Medicina > Cirurgia

Outras Informações

Abstract (EN): Objectives: To evaluate the association between the 4G/5G polymorphism in the promoter of the plasminogen activator inhibitor-1 (PAI-1) gene and deep venous thrombosis (DVT) in young people. Methods: Prevalence of the 4G/5G polymorphism was investigated using DNA analysis in a population of 81 consecutive and unrelated patients with an objectively documented first episode of DVT under 40 years old and in a control group of 88 healthy subjects. Results: The frequency of genotypes among patients was 0.27 4G/4G, 0.49 4G/5G and 0.23 5G/5G, corresponding to a frequency of 0.52 for the 4G allele. In the control group the results were, respectively, 0.24, 0.44 and 0.32, corresponding to a frequency of 0.46 for the 4G allele. The odds ratio (OR) for homozygous 4G genotype was 1,5 (95% confidence interval: 0.7-3.6), which was statistically significant (P = 0.51). Conclusion: In this study, the 4G/5G polymorphism in the promoter of the PAI-1 gene, including the homozygous 4G genotype, was not associated with a significantly increased risk of DVT in young people.

Idioma: Português

Tipo (Avaliação Docente): Científica