Peritumoural, but not intratumoural, lymphatic vessel density and invasion correlate with colorectal carcinoma poor-outcome markers

• Tipo: Artigo em Revista Científica Internacional
• Data: 2008

Autores

Fernando Schmitt (Autor) FMUP

Revista

Título: Virchows Archiv

Vol. 452

Páginas: 133-138

ISSN: 0945-6317

Editora: Springer Nature

Indexação

ISI Web of Knowledge - 22 Citações

Scopus - 22 Citações

Pubmed / Medline

Classificação Científica

FOS: Ciências médicas e da saúde > Medicina básica

CORDIS: Ciências da Saúde > Ciências Médicas > Medicina > Anatomia patológica

Outras Informações

ID Authenticus: P-004-1ZA

DOI: 10.1007/s00428-007-0550-0

Abstract (EN): To evaluate whether lymphatic vessel density (LVD) and lymphatic vessel invasion (LVI) are useful markers of worse outcome in colorectal carcinoma and if LVD and LVI correlate to the classical clinical-pathological parameters, we analysed 120 cases of colorectal carcinomas selected from the files of Division of Pathology, Hospital das Clinicas, Sao Paulo University, Brazil. Assessment of LVD and LVI was performed by immunohistochemical detection of lymphatic vessels, using the monoclonal antibody D2-40. Higher LVD was found in the intratumoural area, when comparing with normal and peritumoural areas (p < 0.001). However, peritumoural LVD, but not intratumoural, correlated with both colonic-wall-invasion depth (p=0.037) and liver metastasis (p=0.012). Remarkably, LVI was found associated with local invasion (p=0.016), nodal metastasis (p=0.022) and hepatic metastasis (p < 0.001). Peritumoural LVD and LVI are directly related to histopathological variables indicative of poor outcome such as lymph-node status and liver metastasis.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 6