Possible use and role of molecular techniques in fine-needle aspiration cytology (FNAC) practice

• Tipo: Artigo em Revista Científica Internacional
• Data: 2011

Autores

Fernando Schmitt (Autor) FMUP

Revista

A Revista está pendente de validação pelos Serviços Administrativos.

Título: Diagnostic Histopathology

Vol. 17

Páginas: 286-292

ISSN: 1756-2317

Indexação

Scopus - 11 Citações

Classificação Científica

FOS: Ciências médicas e da saúde > Outras ciências médicas

Outras Informações

ID Authenticus: P-007-Z1V

DOI: 10.1016/j.mpdhp.2011.05.005

Abstract (EN): Fine-needle aspiration cytology (FNAC) is a recognized ancillary tool in the diagnosis of tumours and infectious diseases. Throughout decades cytopathologists did tremendous marvels with pure morphologic criteria, diagnosing in shrinking amounts of material. The recent understanding of complex cancer biology reshapes the practice of FNAC. The scientific advance of image techniques gave cytopathologists the possibility to go to deep locations and collecting material from previous unlikely locations. This conjunction of knowledge's and techniques has increased the role of FNAC in the diagnosis, prognosis and in the establishment of new therapeutic targets. Lately, core needle biopsy is gaining popularity and advantage regarding FNAC. The sample limitation of FNAC regarding immunocytochemical staining with proper controls, as well as the limitation in appreciating invasiveness has lead, in some fields, like soft tissue tumours, breast, lymph node, and prostate, to diminish the use of FNAC. However FNAC still is a less invasive, effective, and cost efficient technique. In this review we demonstrate the application of basic molecular techniques to FNAC as a crucial tool in the diagnosis, prognosis and planning of alternative molecular therapeutics of tumours. © 2011 Elsevier Ltd.

Idioma: Inglês

Tipo (Avaliação Docente): Científica