Poorly differentiated thyroid carcinoma: The Turin proposal for the use of uniform diagnostic criteria and an algorithmic diagnostic approach

• Tipo: Artigo em Revista Científica Internacional
• Data: 2007

Autores

Volante, M (Autor) Outra; Collini, P (Autor) Outra; Nikiforov, YE (Autor) Outra; Sakamoto, A (Autor) Outra; Kakudo, K (Autor) Outra; Katoh, R (Autor) Outra; Lloyd, RV (Autor) Outra; LiVolsi, VA (Autor) Outra; Mauro, P (Autor) Outra; Sobrinho Simoes, M (Autor) FMUP; Bussolati, G (Autor) Outra; Rosai, J (Autor) Outra

Revista

Título: American Journal of Surgical Pathology

Vol. 31

Páginas: 1256-1264

ISSN: 0147-5185

Editora: Wolters Kluwer Health

Indexação

ISI Web of Knowledge - 176 Citações

Scopus - 196 Citações

Outras Informações

ID Authenticus: P-004-891

DOI: 10.1097/pas.0b013e3180309e6a

Abstract (EN): Poorly differentiated (PD) thyroid carcinomas lie both morphologically and behaviorally between well-differentiated and undifferentiated (anaplastic) carcinomas. Following the original description of this entity, different diagnostic criteria have been employed, resulting in wide discrepancies and confusion among pathologists and clinicians worldwide. To compare lesions occurring in different geographic areas and the diagnostic criteria applied in those countries, we designed a study with a panel of internationally recognized thyroid pathologists to develop consensus diagnostic criteria for PD carcinomas. Eighty-three cases were collected from Europe, Japan, and the United States, and circulated among 12 thyroid pathologists. Diagnoses were made without any knowledge of the clinical parameters, which were subsequently used for survival analysis. A consensus meeting was then held in Turin, Italy, where an agreement was reached concerning the diagnostic criteria for PD carcinoma. These include (1) presence of a solid/trabecular/insular pattern of growth, (2) absence of the conventional nuclear features of papillary carcinoma, and (3) presence of at least one of the following features: convoluted nuclei; mitotic activity >= 3 x 10 HPF; and tumor necrosis. An algorithmic approach was devised for practical use in the diagnosis of this tumor.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 9