Cystic tumor of the atrioventricular node of the heart appears to be the heart equivalent of the solid cell nests (ultimobranchial rests) of the thyroid

• Tipo: Artigo em Revista Científica Internacional
• Data: 2005

Autores

Cameselle Teijeiro, J (Autor) Outra; Abdulkader, I (Autor) Outra; Soares, P (Autor) FMUP; Alfonsin Barreiro, N (Autor) Outra; Moldes Boullosa, J (Autor) Outra; Sobrinho Simoes, M (Autor) FMUP

Revista

Título: American Journal of Clinical Pathology

Vol. 123 Nº 123

Páginas: 369-375

ISSN: 0002-9173

Editora: Oxford University Press

Indexação

ISI Web of Knowledge - 22 Citações

Scopus - 27 Citações

Pubmed / Medline

Classificação Científica

FOS: Ciências médicas e da saúde > Medicina básica

CORDIS: Ciências da Saúde

Outras Informações

ID Authenticus: P-000-4B0

DOI: 10.1309/gwt2py0t77pbba1a

Abstract (EN): We studied a series of 10 solid cell nests (SCNs) of the thyroid and a case of cystic tumor of the atrioventricular node (CTAVN) of the heart and reviewed the literature. The CTAVN and SCNs appeared as cystic and/or solid (squamoid) structures mainly composed of polygonal or oval cells (main cells) admixed with occasional clear cells (neuroendocrine and C cells). Main cells were immunoreactive for simple and stratified epithelial-type cytokeratins, epithelial membrane antigen, carcinoembryonic antigen, carbohydrate antigen 19.9, p63, bcl-2, and galectin-3. Neuroendocrine (and C) cells were positive for simple-type cytokeratins, carcinoembryonic antigen, calcitonin, chromogranin, synaptophysin, and thyroid transcription factor-1. Our data support the hypothesis that the CTAVN of the heart and the SCNs of the thyroid are identical structures that represent the same lesional process. The assumption that CTAVN is a ultimobranchial heterotopia fits with the known role of cardiac neural crest cells in cardiovascular development.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 7