Administration of baclofen, a GABAB agonist, in the thalamic ventrobasal complex attenuates allodynia in monoarthritic rats subjected to the ankle-bend test.

• Tipo: Artigo em Revista Científica Internacional
• Data: 2006

Autores

Potes C.S. (Autor) Outra; Neto F.L. (Autor) FMUP; Castro-Lopes J.M. (Autor) FMUP

Revista

Título: Journal of Neuroscience Research

Vol. 83 Nº 3

Páginas: 515-523

ISSN: 0360-4012

Editora: Wiley-Blackwell

Classificação Científica

CORDIS: Ciências da Saúde > Neurociências > Neuroquímica

Outras Informações

Abstract (EN): gamma-Aminobutyric acid type B (GABAB) receptors are involved in the modulation of neuronal activity in response to chronic noxious input. However, the effect of their activation in chronic inflammatory pain in relay thalamic nuclei such as the ventrobasal complex (VB) is not known. In this study, experimental groups of 2, 4, and 14 days monoarthritic (MA) rats were injected with saline (controls) or baclofen (0.875 microg), a specific GABAB receptor agonist, in the VB contralateral to the inflamed joint, and the ankle-bend test was performed. Ankle-bend scores in control animals were near the maximum and were rather constant throughout the entire experimental period, indicating severe nociception. The same was observed in 2 days MA rats injected with baclofen. In the 4 days MA group, the response to baclofen injection was inconsistent among different animals, whereas, in 14 days MA rats, baclofen caused clear antinociceptive effects. Additionally, a 0.5 microg dose of baclofen was tested in 14 days MA rats, but no effect was observed, whereas a 1.25 mug dose produced visible side effects. Baclofen injections that did not target the VB but reached neighboring nuclei were ineffective in reducing nociception. Data demonstrate that the activation of the GABAB receptors by baclofen in the VB of MA rats leads to a decrease of nociception. Moreover, the response depends on the time course of the disease, suggesting the occurrence of different excitatory states of thalamic VB neurons. In conclusion, GABAB receptors in the VB play an important role in chronic inflammatory pain processing.

Idioma: Português

Tipo (Avaliação Docente): Científica