Aminoterminal B-Type Natriuretic Peptide (NT-proBNP) in End-Stage Renal Failure Patients on Regular Hemodialysis: Does It Have Diagnostic and Prognostic Implications?

• Tipo: Artigo em Revista Científica Internacional
• Data: 2009

Autores

Pimenta J (Autor) FMUP; Sampaio, F (Autor) Outra; Martins, P (Autor) Outra; Carvalho, B (Autor) Outra; Rocha Goncalves, F (Autor) Outra; Ferreira A (Autor) FMUP; Bettencourt P (Autor) FMUP

Revista

Título: Nephron - Clinical Practice

Vol. 111

Páginas: C182-C188

ISSN: 1660-2110

Editora: S. Karger AG

Indexação

ISI Web of Knowledge - 7 Citações

Scopus - 6 Citações

Classificação Científica

FOS: Ciências médicas e da saúde > Outras ciências médicas

Outras Informações

ID Authenticus: P-003-REJ

DOI: 10.1159/000199458

Abstract (EN): Background: Amino-terminal B-type natriuretic peptide (NT-proBNP) quantification is a useful cardiovascular diagnostic and prognostic test. In renal failure its use may have constraints, as it depends on renal clearance. We aimed to evaluate the clinical usefulness of NT-proBNP in hemodialysis (HD) patients. Methods: We measured NT-proBNP levels in 44 patients before and after a regular high-flux HD. Cardiac parameters were evaluated by echocardiography. Patients were followed up for 656.5 +/- 476.4 days for the occurrence of hospital admission or death. Results: NT-proBNP levels decreased after HD (p < 0.0001) without correlation with ultrafiltration volume, Kt/V index, weight decrease or pulse pressure decrease. Pre- and post-HD NT-proBNP were similar in patients with and without left ventricular hypertrophy. Pre- HD levels were not significantly associated with prognosis, probably due to a type 2 error; post-HD NT-proBNP and NT-proBNP reduction ratio (RR) were predictive of the outcome by Kaplan-Meier analysis, but only RR remained associated with prognosis on multivariate regression analysis (hazard ratio 0.96; 95% confidence interval 0.93-0.99). Conclusion: Our results do not support the use of NT-proBNP in the diagnosis of left ventricular hypertrophy or volume status in HD patients, but suggest its utility in prognostic stratification. HD-related variation in NT-proBNP was associated with prognosis. Copyright (C) 2009 S. Karger AG, Basel

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 7