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Urodynamic effect of intravesical resiniferatoxin in patients with neurogenic detrusor overactivity of spinal origin: Results of a double-blind randomized placebo-controlled trial

Título
Urodynamic effect of intravesical resiniferatoxin in patients with neurogenic detrusor overactivity of spinal origin: Results of a double-blind randomized placebo-controlled trial
Tipo
Artigo em Revista Científica Internacional
Ano
2005
Autores
João Silva
(Autor)
FMUP
Maria José Ribeiro
(Autor)
Outra
A pessoa não pertence à instituição. A pessoa não pertence à instituição. A pessoa não pertence à instituição. Sem AUTHENTICUS Sem ORCID
António Avelino Silva
(Autor)
FMUP
Francisco Cruz
(Autor)
FMUP
Revista
Título: European UrologyImportada do Authenticus Pesquisar Publicações da Revista
Vol. 48
Páginas: 650-655
ISSN: 0302-2838
Editora: Elsevier
Classificação Científica
FOS: Ciências médicas e da saúde > Outras ciências médicas
Outras Informações
ID Authenticus: P-000-12D
Abstract (EN): Objectives: To access by a placebo-controlled randomized clinical trial the effect of intravesical resiniferatoxin on the urodynamic parameters of patients with neurogenic detrusor overactivity (NDO) of spinal origin. Methods: Twenty eight patients with spinal NDO were randomised to receive intravesically 50 nM resiniferatoxin dissolved in 10% ethanol in saline (RTX group) or only the vehicle solution (placebo group). Filling cystometries were obtained in each patient at 1 month and 1 week before and at 1 and 3 months after treatment. In a visual analog scale patients were asked to estimate the discomfort induced by treatment. Patients were also persuaded to fill a micturition chart during the 3 days preceding each cystometry. Results: The RTX and placebo groups were homogeneous in what respects the volume to first involuntary detrusor contraction (FDC, 143 +/- 95 ml and 115 +/- 58 ml, respectively, p = 0.3) and maximal cystometric capacity (MCC, 189 +/- 99 ml and 198 +/- 111 ml, respectively, p = 0.8). At the end of the study, mean FDC and MCC in the RTX group, 184 +/- 93 ml and 314 +/- 135 ml, respectively were significantly higher than in the placebo group, 115 +/- 61 ml (p = 0.03) and 204 +/- 92 ml (p = 0.02). In the visual analogue scale discomfort caused by treatment was similar. Only 10 patients in the RTX group and 6 patients in the placebo group completed adequately the micturition chart. Mean frequency and urinary incontinence decreased significantly only in the RTX group. Conclusions: Intravesical RTX is effective in increasing bladder capacity in spinal NDO patients. Such increment might contribute to decrease urinary frequency and incontinence of these patients.
Idioma: Inglês
Tipo (Avaliação Docente): Científica
Nº de páginas: 6
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