Hereditary gastric cancer

• Tipo: Artigo em Revista Científica Internacional
• Data: 2009

Autores

Oliveira C (Autor) FMUP; Seruca R (Autor) FMUP; Carneiro F (Autor) FMUP

Revista

Título: Best Practice and Research in Clinical Gastroenterology

Vol. 23

Páginas: 147-157

ISSN: 1521-6918

Editora: Elsevier

Indexação

ISI Web of Knowledge - 48 Citações

Scopus - 59 Citações

Classificação Científica

FOS: Ciências médicas e da saúde > Outras ciências médicas

Outras Informações

ID Authenticus: P-003-KYM

DOI: 10.1016/j.bpg.2009.02.003

Abstract (EN): Gastric cancer is a heterogeneous and highly prevalent disease, being the fourth most common cancer and the second leading cause of cancer associated death worldwide. Most cases are sporadic and familial clustering is observed in about 10% of the cases. Hereditary gastric cancer accounts for a very low percentage of cases (1-3%) and a single hereditary syndrome - Hereditary Diffuse Gastric Cancer (HDGC) - has been characterised. Among families that fulfil the clinical criteria for HDGC, about 40% carry CDH1 germline mutations, the genetic cause of the others being unknown. The management options for CDH1 asymptomatic germline carriers are intensive endoscopic Surveillance and prophylactic gastrectomy. In this chapter we review the pathophysiology and clinicopathological features of HDGC and discuss issues related with genetic testing and management of family members.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 11