REGULATION OF DOPAMINE SYNTHESIS IN THE RAT-KIDNEY

• Tipo: Artigo em Revista Científica Internacional
• Data: 1990

Autores

Soares-da-Silva P (Autor) Outra; Fernandes MH (Autor) FMDUP

Revista

Título: Journal of Autonomic Pharmacology

Vol. 10

Páginas: S25-S30

ISSN: 0144-1795

Editora: Blackwell

Indexação

ISI Web of Knowledge - 67 Citações

Classificação Científica

FOS: Ciências médicas e da saúde > Outras ciências médicas

Outras Informações

ID Authenticus: P-001-S5A

DOI: 10.1111/j.1474-8673.1990.tb00224.x

Abstract (EN): 1 Both animal and clinical studies clearly suggest a close link between dopamine production and renal delivery of sodium. 2 It appears that tubular transport of sodium and DOPA could represent the rate limiting step for the renal synthesis of dompamine; the membrane transport mechanism is sensitive to the nucleotide cyclic GMP. 3 In sodium overloaded animals AAAD activity appears to be greater than that in controls, but the tubular transport of L-DOPA might be decreased. 4 Since the final product of an increased sodium delivery to the kidney is an increased urinary excretion of dopamine, it might be hypothesized that the outward transport of newly formed dopamine in tubular epithelial cells is also affected by high tubular sodium.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 6