Isotropic micropatterned silica coatings on zirconia induce guided cell growth for dental implants

• Tipo: Artigo em Revista Científica Internacional
• Data: 2011

Autores

A. Pelaez-Vargas (Autor) Outra; D. Gallego-Perezc (Autor) Outra; M. Magallanes-Perdomo (Autor) Outra; M. H. Fernandes (Autor) FMDUP; D.J. Hansfordc (Autor) Outra; H. De Aza (Autor) Outra; P. Pena (Autor) Outra; F. J. Monteiro (Autor) FEUP

Revista

Título: Dental Materials

Vol. 27 Nº 6

Páginas: 581-589

ISSN: 0109-5641

Editora: Elsevier

Indexação

ISI Web of Knowledge - 36 Citações

ISI Web of Science

Scopus - 40 Citações

Pubmed / Medline

Classificação Científica

FOS: Ciências médicas e da saúde > Outras ciências médicas

CORDIS: Ciências da Saúde

Outras Informações

ID Authenticus: P-002-R8E

DOI: 10.1016/j.dental.2011.02.014

Abstract (EN): Titanium implants are the gold standard in dentistry; however, problems such as gingival tarnishing and peri-implantitis have been reported. For zirconia to become a competitive alternative dental implant material, surface modification techniques that induce guided tissue growth must be developed. Objectives: To develop alternative surface modification techniques to promote guided tissue regeneration on zirconia materials, for applications in dental implantology. Methods: A methodology that combined soft lithography and sol-gel chemistry was used to obtain isotropic micropatterned silica coatings on yttria-stabilized zirconia substrates. The materials were characterized via chemical, structural, surface morphology approaches. In vitro biological behavior was evaluated in terms of early adhesion and viability/metabolic activity of human osteoblast-like cells. Statistical analysis was conducted using one-way ANOVA/Tukey HSD post hoc test. Results: Isotropic micropatterned silica coatings on yttria-stabilized zirconia substrates were obtained using a combined approach based on sol-gel technology and soft lithography. Micropatterned silica surfaces exhibited a biocompatible behavior, and modulated cell responses (i.e. inducing early alignment of osteoblast-like cells). After 7 d of culture, the cells fully covered the top surfaces of pillar microstructured silica films. Significance: The micropatterned silica films on zirconia showed a biocompatible response, and were capable of inducing guided osteoblastic cell adhesion, spreading and propagation. The results herein presented suggest that surface-modified ceramic implants via soft lithography and sol-gel chemistry could potentially be used to guide periodontal tissue regeneration, thus promoting tight tissue apposition, and avoiding gingival retraction and peri-implantitis. © 2011 Academy of Dental Materials. Published by Elsevier Ltd. All rights reserved.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 9