IN-VIVO EFFECTS OF THE MONOAMINE-OXIDASE INHIBITORS RO-41-1049 AND RO-19-6327 ON THE PRODUCTION AND FATE OF RENAL DOPAMINE

• Tipo: Artigo em Revista Científica Internacional
• Data: 1994

Autores

Vieira-Coelho MA (Autor) Outra; Fernandes MH (Autor) FMDUP; Soares-da-Silva P (Autor) Outra

Revista

Título: Journal of Neural Transmission, Supplement

Páginas: 365-370

ISSN: 0303-6995

Editora: Springer

Indexação

ISI Web of Knowledge - 8 Citações

Scopus - 11 Citações

Classificação Científica

FOS: Ciências médicas e da saúde > Outras ciências médicas

Outras Informações

ID Authenticus: P-001-KVW

Abstract (EN): Ro 41-1049 (2 mg/kg), but not Ro 19-6327 (2 mg/kg), was found to reduce (70% to 93% decrease) DOPAC tissue levels in the renal cortex, outer and inner medulla and, to a similar extent, DOPAC concentrations in plasma. This inhibitory effect was, however, not accompained by an increased accumulation of newly-formed dopamine. The results presented show that type A monoamine oxidase is the predominant form of the enzyme involved in the metabolism of renal dopamine and some of the amine which escapes deamination might leave the kidney through the renal vein in the intact from.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 6